RESEARCH INTERESTS

RESEARCH INTERESTS

Our lab is focused on exploring the cellular interactions which underlie varied pathological conditions and developing translational technologies which leverage this interactome, for potential clinical applications. We are building the lab based on our success in developing a platelet-based therapeutic with anti-platelet and anti-metastatic effect (Papa et al., Science Translational Medicine, 2019). This work was achieved with the support of our DoD Breast Cancer Breakthrough Award.​​

We aim to pursue the 3 following avenues over the next few years:

  • Developing diagnostic and therapeutic tools based on an integration of cellular components and nanotechnology, for cancer and thrombosis

  • Understanding platelet-immune cell interactions in physiological and pathological scenarios

  • Understanding the effect of nanomedicine/nanotechnology on normal hemostasis

KEY WORDS

Cancer - Metastasis - Thrombosis - Platelets - Nanotechnology - Drug delivery - Diagnostic tools

OUR RESEARCH PHOTO GALLERY

Human Umbilical Vascular Endothelial Cell tube formation assay

Human Umbilical Vascular Endothelial Cell tube formation assay

Human Umbilical Vascular Endothelial Cell tube formation assay
Wound healing assay using
MCF-7 breast cancer cells
Transmission Electron Micrograph of"platelet decoys" or detergent extracted human platelets
Transmission Electron Micrograph of"human platelets
Scanning Electron Micrograph of activated platelets
Confocal image of"platelets (magenta)interacting with a breast cancer cell