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  • BME 6045 Special Topics – Nanomedicine & Drug Delivery (Spring 2018, 2019, 2020, 2021, 2022)

 

Nanomedicine & Drug Delivery is a 3-credit lecture-based course including discussion sections on recent publications, as well as pioneering literature in the field. This course covers the multiple aspects of the field of nanoparticle-based drug delivery from the basic concepts of syntheses and characterization of nanoparticles, to their surface functionalization and activity in vitro and in vivo. Specifically, the course highlights the parameters that modulate nanoparticle interaction with proteins and cells in vitro, as well as their biodistribution. Multiple applications are presented from imaging pathologies utilizing nanoparticles to therapeutic platforms in drug delivery. 

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Confocal microscopy image of the internalization of coumarin-loaded PLGA nanoparticles (yellow) in 4T1 murine breast cancer cells (blue: nuclei; magenta: plasma membrane).
Image credit: A-L Papa

  •  BME 6045 Special Topics – Biology of Materials and Regenerative Medicine (Fall 2018, 2019, 2020, 2021, 2022)

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Biology of Materials and Regenerative Medicine  is a 3-credit lecture-based course that covers the basic principles of Biology, Hematology and Immunology directly related to biomaterials and regenerative medicine. The course includes lectures as well as discussions of literature on topics such as: blood cell physiology and blood interfacing materials, cell and surfaces, cell function and response to injury, basics of the immune response, organs-on-chips, cell therapy, biomaterial evaluation and potential toxicity.

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Human organs-on-chips, such as the one pictured here and developed by Donald E. Ingber, MD, PhD (Wyss Institute at Harvard University), replicate organ level function and enable the study of organ physiology, pathophysiology or perform high throughput drug screening.
Image credit: Wyss Institute at Harvard University
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